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New advances in understanding the mechanisms and treatment challenges of ALK-targeted therapy resistance in lung cancer
Open Access Review 25 Aug 2025
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ROS1 mutations promote an immunosuppressive tumor microenvironment via MYC to confer immune evasion in head and neck cancer
Open Access Original Article 22 Aug 2025
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IRE1α modulates M1 oncolytic virus sensitivity via ER stress regulation in bladder cancer
Open Access Original Article 13 Aug 2025
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Corosolic acid increases the therapeutic effect of cisplatin on gastric cancer by regulating Gpx4-dependent ferroptosis
Open Access Original Article 7 Aug 2025
DOI: 10.20517/cdr.2025.94
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Lactylation: a novel driver of drug resistance in the tumor microenvironment
Open Access Review 4 Aug 2025
DOI: 10.20517/cdr.2025.90
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Effects of FAP+ cancer-associated fibroblasts on anti-PD-1 immunotherapy and CD4+ T cell polarization in gastric cancer
Open Access Original Article 29 Jul 2025
DOI: 10.20517/cdr.2025.97
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Super-enhancer inhibitors THZ2 and JQ1 reverse temozolomide resistance in glioblastoma by suppressing SE-driven SOX9 expression
Open Access Original Article 22 Jul 2025
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Decoding breast cancer treatment resistance through genetic, epigenetic, and immune-regulatory mechanisms: from molecular insights to translational perspectives
Open Access Review 21 Jul 2025
DOI: 10.20517/cdr.2025.69
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CF10/LV overcomes acquired resistance to 5-FU/LV in colorectal cancer cells through downregulation of the c-Myc/ABCB5 axis
Open Access Original Article 15 Jul 2025
DOI: 10.20517/cdr.2025.76
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The next frontier in antibody-drug conjugates: challenges and opportunities in cancer and autoimmune therapy
Open Access Review 3 Jul 2025
DOI: 10.20517/cdr.2025.49
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Interactions between tumor microenvironment and resistance to transarterial and systemic treatments for HCC
Open Access Review 2 Jul 2025
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Modeling methods of different tumor organoids and their application in tumor drug resistance research
Open Access Review 1 Jul 2025
DOI: 10.20517/cdr.2025.34
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Integrated multi-omics profiling of immune microenvironment and drug resistance signatures for precision prognosis in prostate cancer
Open Access Original Article 25 Jun 2025
DOI: 10.20517/cdr.2025.47
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MicroRNA-mediated autophagy regulation in thyroid cancer drug resistance
Open Access Mini Review 18 Jun 2025
DOI: 10.20517/cdr.2025.73
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Antibody-drug conjugates in breast cancer: current resistance mechanisms and future combination strategies
Open Access Review 17 Jun 2025
DOI: 10.20517/cdr.2025.26
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Fibroblast growth factor receptor alterations and resistance mechanisms in the treatment of pediatric solid tumors
Open Access Original Article 6 Jun 2025
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Acquired resistance to molecularly targeted therapies for cancer
Open Access Review 5 Jun 2025
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PER2 expression and cellular localization play a critical role in tumor aggressiveness and drug resistance in an in vitro model of hepatocellular carcinoma
Open Access Original Article 3 Jun 2025
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