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Volume 6, Issue 2 (2026) – 18 articles

Cover Picture: Coming soon.

Review

Navigating gut-liver metabolic homeostasis: the role of the autonomic nervous system

Run Sun, ... Jin Chai

Metab Target Organ Damage. 2026;6:26. DOI: 10.20517/mtod.2026.37

Review | Available online: 8 Jun 2026

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Pharmacologic management of metabolic and alcohol-associated liver disease

Mangesh Pagadala, ... Ashwani K. Singal

Metab Target Organ Damage. 2026;6:33. DOI: 10.20517/mtod.2026.29

Review | Available online: 16 Jun 2026

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Podocyte lipotoxicity in diabetic kidney disease: mechanisms and targets

Mengsi Hu, ... Chaoyue Yan

Metab Target Organ Damage. 2026;6:30. DOI: 10.20517/mtod.2026.24

Review | Available online: 10 Jun 2026

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Application and interpretation of non-invasive testing in MetALD

Wah-Kheong Chan, ... Vincent Wai-Sun Wong

Metab Target Organ Damage. 2026;6:21. DOI: 10.20517/mtod.2026.30

Review | Available online: 25 May 2026

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Original Article

Advanced glycation endproduct-RAGE signaling fosters diabetic cardiomyopathy by enhancing cuproptosis and mitochondrial injury

Fengjuan Li, ... Jun Ren

Metab Target Organ Damage. 2026;6:32. DOI: 10.20517/mtod.2026.36

Original Article | Available online: 12 Jun 2026

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Sex and age genetic overlap between body mass index and attention deficit hyperactivity disorder in twins

Tian-Jiao Chen, ... Zheng Chang

Metab Target Organ Damage. 2026;6:28. DOI: 10.20517/mtod.2026.32

Original Article | Available online: 8 Jun 2026

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Variation spectrum and reevaluation of selected VUS of ATP7B in a Chinese Wilson disease cohort

Leilei Gu, ... Yue Han

Metab Target Organ Damage. 2026;6:27. DOI: 10.20517/mtod.2026.01

Original Article | Available online: 8 Jun 2026

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Thrombospondin 1 is associated with MASH and hepatic macrophage inflammatory responses via CD47

Qiling Liu, ... Hua Bian

Metab Target Organ Damage. 2026;6:25. DOI: 10.20517/mtod.2026.11

Original Article | Available online: 3 Jun 2026

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Genetic predisposition to diabetes mellitus causally increases acute pancreatitis risk

Yi-Man Wang, ... Tuo Li

Metab Target Organ Damage. 2026;6:24. DOI: 10.20517/mtod.2025.221

Original Article | Available online: 28 May 2026

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The impact of phthalate exposure on cardiometabolic risk progression in children and the modifying role of movement behaviors

Ruolin Wang, ... Yanhui Dong

Metab Target Organ Damage. 2026;6:23. DOI: 10.20517/mtod.2025.229

Original Article | Available online: 27 May 2026

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Alterations in the serum lipid profile predict incident diabetes in obese individuals

Juan Du, ... Shan Huang

Metab Target Organ Damage. 2026;6:22. DOI: 10.20517/mtod.2025.206

Original Article | Available online: 25 May 2026

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High glucose induces hypoxanthine accumulation, linking hyperglycemia to adipocyte dysfunction

Zhongxiao Zhang, ... Jianfang Gao

Metab Target Organ Damage. 2026;6:20. DOI: 10.20517/mtod.2025.215

Original Article | Available online: 19 May 2026

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Metabolic biomarkers predict subclinical cardiac remodeling in obese individuals

Mengjie Hu, ... Zhen Li

Metab Target Organ Damage. 2026;6:19. DOI: 10.20517/mtod.2025.183

Original Article | Available online: 9 May 2026

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Commentary

Incretin-based therapy for MASH: are two better than one?

Richard K. Sterling

Metab Target Organ Damage. 2026;6:34. DOI: 10.20517/mtod.2026.74

Commentary | Available online: 17 Jun 2026

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Mechanism-driven therapy for diabetic cardiovascular disease

Fabian Sanchis-Gomar, ... Ian J. Neeland

Metab Target Organ Damage. 2026;6:31. DOI: 10.20517/mtod.2026.84

Commentary | Available online: 10 Jun 2026

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Wilson disease revisited: is the gut a metabolically vulnerable target organ?

Dominique Debray, ... Aurelia Poujois

Metab Target Organ Damage. 2026;6:29. DOI: 10.20517/mtod.2026.40

Commentary | Available online: 9 Jun 2026

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Semaglutide in MASH with F2-F3 fibrosis: a holistic perspective on the ESSENCE phase 3 trial

Carlos Jose Pirola, ... Silvia Sookoian

Metab Target Organ Damage. 2026;6:17. DOI: 10.20517/mtod.2026.13

Commentary | Available online: 16 Apr 2026

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Reconsidering metabolic adaptation in weight loss evidence: insights and potential limitations of tirzepatide-induced fat oxidation

Mohammad T. Alashqar, ... Milap C. Nahata

Metab Target Organ Damage. 2026;6:18. DOI: 10.20517/mtod.2025.235

Commentary | Available online: 29 Apr 2026

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