fig2

Figure 2. Functions of RNA-binding proteins in bone diseases. The main mechanism of RNA-binding proteins (RBPs) in osteoporosis (A), spinal diseases (B) and rheumatoid arthritis (C) is summarized in this figure. HUR: Human antigen R; lnc-PMIF: long non-coding RNA postulated migration inhibitory factor; circStag1: circular RNA Stag1; METTL14: methyltransferase-like 14; METTL3: methyltransferase-like 3; WTAP: wilms tumor 1-associated protein; ALKBH5: AlkB homologue 5; FTO: fat-mass and obesity-associated protein; NF-κB: nuclear factor-kappa B; IVDD: intervertebral disc degeneration; OPLL: ossification of the posterior longitudinal ligament; RBMS3: RNA binding protein motif single stranded interacting protein 3; lnc-NORAD: long non-coding RNA non-coding RNA activated by DNA damage; NKRF: NF-kappaB repressing factor; ECM: extracellular matrix; CDC5L: cell division cycle 5-like; PCBP1: poly(rC)-binding protein 1; hnRNP UL1: heterogeneous nuclear ribonucleoprotein U-like 1; CIRP: cold-inducible RBP; p54^nrb: 54-kDa nuclear RNA-binding protein; SAM68: Src associated during mitosis of 68 kDa.