fig2

Figure 2. Joint association (95%CI) of the mixture on hormone levels. (A) Observe the combined effect (95%CI) of the selected chemical group and HCG_E2/Basal_P through the BKMR model; (B and C) The correlation between a single chemical and HCG_E2 and Basal_P when all other exposed compounds are fixed at the 25th, 50th, or 75th percentile of exposure. The univariate exposure-response function (95%CI) of the selected chemical concentration on HCG_E2 and Basal_P. h(Z) is interpreted as the relationship between the chemical and the potential continuous outcome; (D) The Qgcomp model is used to reveal a bar chart of the relative weight of each chemical and its influence on hormone levels. HCG_E2: Estradiol on HCG trigger day; Basal_P: basal progesterone; BKMR: Bayesian kernel machine regression.