fig1
From: Drug resistance in metastatic castration-resistant prostate cancer: an update on the status quo
Figure 1. Mechanisms of drug resistance in mCRPC. Several mechanisms of drug resistance are well defined in CRPC, including AR amplification and overexpression, AR point mutations, AR post-translational modifications, AR splice variants, AR co-regulators, altered steroidogenesis, GR overexpression, neuroendocrine differentiation, tumor microenvironment, and other signaling alterations. AR: Androgen receptor; GR: glucocorticoid receptor; mCRPC: metastatic castration-resistance prostate cancer.
