fig1

Figure 1. Types and structural organization of NF proteins. Adapted and modified from Yuan et al. (2017)^[14], with additional graphical modifications and redesign by the authors. © Cold Spring Harbor Laboratory Press. Adapted with permission. Schematic illustration depicts the conserved three-domain architecture (N-terminal head, central rod, C-terminal tail) of NF subunits (NfL, NfM, NfH) and related neuronal intermediate filaments (α-internexin, peripherin), along with key post-translational modification sites including phosphorylation and O-linked glycosylation. Created with BioGDP.com. NF: Neurofilament; NfL: neurofilament light chain; NfM: neurofilament medium chain; NfH: neurofilament heavy chain.