Mini Review | Open Access
A new route for mitigating age-related cognitive decline
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Ageing Neur Dis 2025;5:[Accepted].
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Abstract
The dynamic relationship between neuronal activity and mitochondrial function plays a crucial role in cognitive health, with disruptions linked to age-related cognitive decline. In this mini review, we highlight the significant findings of Li et al., who discovered an age-dependent coupling mechanism between neuronal/synaptic excitation and excitation-dependent mitochondrial gene expression (E-TCmito). Their research revealed that enhancing brain E-TCmito in aged animals effectively mitigated age-related cognitive decline.
Keywords
CREB, CaMKII, mitochondrial gene expression, age-related cognitive decline, neuronal excitation, synaptic excitation
Cite This Article
Chen H, Cao L, Liu S, Yuan K. A new route for mitigating age-related cognitive decline. Ageing Neur Dis 2025;5:[Accept]. http://dx.doi.org/10.20517/and.2025.16
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© The Author(s) 2025. Open Access This article is licensed under a Creative Commons Attribution 4.0 International License (https://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, sharing, adaptation, distribution and reproduction in any medium or format, for any purpose, even commercially, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made.
