fig5

Figure 5. Establishment of butyrogenic guilds and identification of keystone species following the cranberry extract supplementation. (A and B) Networks of significant co-occurrences between the bacterial species (ASV) based on 16S rRNA gene amplicon sequencing in the transverse colon for the lumen (A) and the mucus (B) during the second week of supplementation. The nodes are shaped according to the corresponding phylum and the edges indicate a positive (full lines) or negative (dotted lines) correlation between the network nodes. From the networks, bacterial guilds are displayed. Red nodes indicate the ASVs identified as keystone species according to network analysis of high degree, low betweenness centrality, and high closeness centrality simultaneously significant at the α = 0.05 interval.