REFERENCES
1. Zheng, M.; Wang, X.; Chen, Y.; et al. A review of recent progress on collagen-based biomaterials. Adv. Healthc. Mater. 2023, 12, e2202042.
3. Shoulders, M. D.; Raines, R. T. Collagen structure and stability. Annu. Rev. Biochem. 2009, 78, 929-58.
4. Amirrah, I. N.; Lokanathan, Y.; Zulkiflee, I.; Wee, M. F. M. R.; Motta, A.; Fauzi, M. B. A Comprehensive review on collagen type I development of biomaterials for tissue engineering: from biosynthesis to bioscaffold. Biomedicines 2022, 10, 2307.
5. Oslan, S. N. H.; Shapawi, R.; Mokhtar, R. A. M.; Noordin, W. N. M.; Huda, N. Characterization of acid- and pepsin-soluble collagen extracted from the skin of purple-spotted bigeye snapper. Gels 2022, 8, 665.
6. Jafari, H.; Lista, A.; Siekapen, M. M.; et al. Fish collagen: extraction, characterization, and applications for biomaterials engineering. Polymers 2020, 12, 2230.
7. Bigi, A.; Panzavolta, S.; Rubini, K. Relationship between triple-helix content and mechanical properties of gelatin films. Biomaterials 2004, 25, 5675-80.
8. Pawelec, K. M.; Best, S. M.; Cameron, R. E. Collagen: a network for regenerative medicine. J. Mater. Chem. B. 2016, 4, 6484-96.
9. Sarrigiannidis, S.; Rey, J.; Dobre, O.; González-García, C.; Dalby, M.; Salmeron-Sanchez, M. A tough act to follow: collagen hydrogel modifications to improve mechanical and growth factor loading capabilities. Mater. Today. Bio. 2021, 10, 100098.
10. Knight, C. G.; Morton, L. F.; Peachey, A. R.; Tuckwell, D. S.; Farndale, R. W.; Barnes, M. J. The collagen-binding A-domains of Integrins α1β1 and α2β1recognize the same specific amino acid sequence, GFOGER, in native (triple-helical) collagens. J. Biol. Chem. 2000, 275, 35-40.
11. Raynal, N.; Hamaia, S. W.; Siljander, P. R.; et al. Use of synthetic peptides to locate novel integrin α2β1-binding motifs in human collagen III. J. Biol. Chem. 2006, 281, 3821-31.
12. Sun, Z.; Guo, S. S.; Fässler, R. Integrin-mediated mechanotransduction. J. Cell. Biol. 2016, 215, 445-56.
13. Panciera, T.; Azzolin, L.; Cordenonsi, M.; Piccolo, S. Mechanobiology of YAP and TAZ in physiology and disease. Nat. Rev. Mol. Cell. Biol. 2017, 18, 758-70.
14. Page-Mccaw, A.; Ewald, A. J.; Werb, Z. Matrix metalloproteinases and the regulation of tissue remodelling. Nat. Rev. Mol. Cell. Biol. 2007, 8, 221-33.
15. Rowley, J. A.; Mooney, D. J. Alginate type and RGD density control myoblast phenotype. J. Biomed. Mater. Res. 2002, 60, 217-23.
16. Burdick, J. A.; Prestwich, G. D. Hyaluronic acid hydrogels for biomedical applications. Adv. Mater. 2011, 23, H41-56.
17. Sorushanova, A.; Delgado, L. M.; Wu, Z.; et al. The collagen suprafamily: from biosynthesis to advanced biomaterial development. Adv. Mater. 2018, 31, 1801651.
18. Gu, L.; Shan, T.; Ma, Y.; Tay, F. R.; Niu, L. Novel biomedical applications of crosslinked collagen. Trends. Biotechnol. 2019, 37, 464-91.
19. Cheema, U.; Rong, Z.; Kirresh, O.; Macrobert, A. J.; Vadgama, P.; Brown, R. A. Oxygen diffusion through collagen scaffolds at defined densities: implications for cell survival in tissue models. J. Tissue. Eng. Regen. Med. 2012, 6, 77-84.
20. Raub, C.; Putnam, A.; Tromberg, B.; George, S. Predicting bulk mechanical properties of cellularized collagen gels using multiphoton microscopy. Acta. Biomater. 2010, 6, 4657-65.
21. Daly, A. C.; Riley, L.; Segura, T.; Burdick, J. A. Hydrogel microparticles for biomedical applications. Nat. Rev. Mater. 2020, 5, 20-43.
22. Kamperman, T.; Karperien, M.; Le Gac, S.; Leijten, J. Single-cell microgels: technology, challenges, and applications. Trends. Biotechnol. 2018, 36, 850-65.
23. Xuan, L.; Hou, Y.; Liang, L.; et al. Microgels for cell delivery in tissue engineering and regenerative medicine. Nano-Micro. Lett. 2024, 16, 218.
24. Griffin, D. R.; Weaver, W. M.; Scumpia, P. O.; Di Carlo, D.; Segura, T. Accelerated wound healing by injectable microporous gel scaffolds assembled from annealed building blocks. Nat. Mater. 2015, 14, 737-44.
25. Feng, Q.; Li, D.; Li, Q.; Cao, X.; Dong, H. Microgel assembly: fabrication, characteristics and application in tissue engineering and regenerative medicine. Bioact. Mater. 2022, 9, 105-19.
26. Muir, V. G.; Qazi, T. H.; Shan, J.; Groll, J.; Burdick, J. A. Influence of microgel fabrication technique on granular hydrogel properties. ACS. Biomater. Sci. Eng. 2021, 7, 4269-81.
27. Harris, J. R.; Soliakov, A.; Lewis, R. J. In vitro fibrillogenesis of collagen type I in varying ionic and pH conditions. Micron 2013, 49, 60-8.
28. Lehnert, S.; Sikorski, P. Tailoring the assembly of collagen fibers in alginate microspheres. Mat. Sci. Eng. C. 2021, 121, 111840.
29. Gobeaux, F.; Mosser, G.; Anglo, A.; et al. Fibrillogenesis in dense collagen solutions: a physicochemical study. J. Mol. Biol. 2008, 376, 1509-22.
30. Achilli, M.; Mantovani, D. Tailoring mechanical properties of collagen-based scaffolds for vascular tissue engineering: the effects of pH, temperature and ionic strength on gelation. Polymers 2010, 2, 664-80.
31. Cheng, X.; Gurkan, U. A.; Dehen, C. J.; et al. An electrochemical fabrication process for the assembly of anisotropically oriented collagen bundles. Biomaterials 2008, 29, 3278-88.
32. Holder, A. J.; Badiei, N.; Hawkins, K.; Wright, C.; Williams, P. R.; Curtis, D. J. Control of collagen gel mechanical properties through manipulation of gelation conditions near the sol-gel transition. Soft. Matter. 2018, 14, 574-80.
33. Hong, S.; Hsu, H.; Kaunas, R.; Kameoka, J. Collagen microsphere production on a chip. Lab. Chip. 2012, 12, 3277.
34. Samiei, E.; Veres, T.; Günther, A. Microfluidic synthesis of collagen-based microgels for tissue engineering applications. Nano. Select. 2025, 6, e202400121.
35. Antoine, E. E.; Vlachos, P. P.; Rylander, M. N. Review of collagen I hydrogels for bioengineered tissue microenvironments: characterization of mechanics, structure, and transport. Tissue. Eng. Part. B-Re. 2014, 20, 683-96.
36. Gong, X.; Wen, Z.; Liang, Z.; et al. Instant assembly of collagen for tissue engineering and bioprinting. Nat. Mater. 2025, 24, 1307-18.
37. Zhao, H.; Wang, Z.; Jiang, S.; et al. Microfluidic synthesis of injectable angiogenic microgels. Cell. Rep. Phys. Sci. 2020, 1, 100047.
38. Davidenko, N.; Schuster, C.; Bax, D.; et al. Control of crosslinking for tailoring collagen-based scaffolds stability and mechanics. Acta. Biomater. 2015, 25, 131-42.
39. Beghetto, V.; Gatto, V.; Conca, S.; Bardella, N.; Scrivanti, A. Polyamidoamide dendrimers and cross-linking agents for stabilized bioenzymatic resistant metal-free bovine collagen. Molecules 2019, 24, 3611.
40. Olde Damink, L. H. H.; Dijkstra, P. J.; Van Luyn, M. J. A.; Van Wachem, P. B.; Nieuwenhuis, P.; Feijen, J. Glutaraldehyde as a crosslinking agent for collagen-based biomaterials. J. Mater. Sci:. Mater. Med. 1995, 6, 460-72.
41. Macaya, D.; Ng, K. K.; Spector, M. Injectable collagen-genipin gel for the treatment of spinal cord injury: in vitro studies. Adv. Funct. Mater. 2011, 21, 4788-97.
42. Drzewiecki, K. E.; Malavade, J. N.; Ahmed, I.; Lowe, C. J.; Shreiber, D. I. A thermoreversible, photocrosslinkable collagen bio-ink for free-form fabrication of scaffolds for regenerative medicine. Technology 2017, 05, 185-95.
43. Orban, J. M.; Wilson, L. B.; Kofroth, J. A.; El-Kurdi, M. S.; Maul, T. M.; Vorp, D. A. Crosslinking of collagen gels by transglutaminase. J. Biomed. Mater. Res. 2004, 68A, 756-62.
44. Chen, R.; Ho, H.; Sheu, M. Characterization of collagen matrices crosslinked using microbial transglutaminase. Biomaterials 2005, 26, 4229-35.
45. Eyre, D. R.; Weis, M.; Rai, J. Analyses of lysine aldehyde cross-linking in collagen reveal that the mature cross-link histidinohydroxylysinonorleucine is an artifact. J. Biol. Chem. 2019, 294, 6578-90.
46. Snider, C.; Bellrichard, M.; Meyer, A.; Kannan, R.; Grant, D.; Grant, S. A novel crosslinker-free technique toward the fabrication of collagen microspheres. J. Biomed. Mater. Res. 2020, 108, 2789-98.
47. Berthold, A.; Cremer, K.; Kreuter, J. Collagen microparticles: carriers for glucocorticosteroids. Eur. J. Pharm. Biopharm. 1998, 45, 23-9.
48. Rössler, B.; Kreuter, J.; Scherer, D. Collagen microparticles: preparation and properties. J. Microencapsulation. 1995, 12, 49-57.
49. Teng, S.; Liang, M.; Wang, P.; Luo, Y. Biomimetic composite microspheres of collagen/chitosan/nano-hydroxyapatite: In-situ synthesis and characterization. Materials. Mater. Sci. Eng. C. 2016, 58, 610-3.
50. Devernois, E.; Coradin, T. A top-down approach to dense collagen I-chitosan microgels and granular hydrogels. ChemRxiv 2025. Available online: https://doi.org/10.26434/chemrxiv-2025-rrcq8. [accessed 6 July 2026].
51. Hong, C.; Lee, Y.; Chung, H.; et al. Micro-fragmented collagen hydrogel wound dressing: Enhanced porosity facilitates elevated stem cell survival and paracrine effects for accelerated wound maturation. Mater. Today. Bio. 2025, 32, 101678.
52. Van Der Heide, D.; Del Toro Runzer, C.; Della Bella, E.; et al. Implementing BMP-7 chemically modified RNA for bone regeneration with 3D printable hyaluronic acid-collagen granular gels. Adv. Healthc. Mater. 2025, 14, 2405047.
53. Barberi, G.; Biscari, G.; Palumbo, F. S.; et al. Exploring marine collagen application in the formulation of microparticles as scaffold doping agents in tissue engineering. J. Drug. Delivery. Sci. Technol. 2025, 114, 107433.
54. Santos, D.; Maurício, A. C.; Sencadas, V.; Santos, J. D.; Fernades, M. H.; Gomes, R. S. In: Biomaterials - physics and chemistry - new edition. Spray drying: an overview. IntechOpen, 2018; pp 9-36.
55. Du, B.; Feng, S.; Wang, J.; et al. Collagen-based micro/nanogel delivery systems: manufacturing, release mechanisms, and biomedical applications. Chin. Med. J. (Engl). 2025, 138, 1135-52.
56. Wang, J.; Jansen, J. A.; Yang, F. Electrospraying: possibilities and challenges of engineering carriers for biomedical applications - a mini review. Front. Chem. 2019, 7, 258.
57. Jayakumar, G. C.; Usharani, N.; Kawakami, K.; Rao, J. R.; Nair, B. U. Preparation of antibacterial collagen-pectin particles for biotherapeutics. RSC. Adv. 2014, 4, 42846-54.
58. Jiang, W.; Li, M.; Chen, Z.; Leong, K. W. Cell-laden microfluidic microgels for tissue regeneration. Lab. Chip. 2016, 16, 4482-506.
59. Wei, Z.; Wang, S.; Hirvonen, J.; Santos, H. A.; Li, W. Microfluidics fabrication of micrometer-sized hydrogels with precisely controlled geometries for biomedical applications. Adv. Healthc. Mater. 2022, 11, 2200846.
60. Matsunaga, Y. T.; Morimoto, Y.; Takeuchi, S. Molding cell beads for rapid construction of macroscopic 3D tissue architecture. Adv. Mater. 2011, 23, H90-4.
61. Yamada, M.; Hori, A.; Sugaya, S.; et al. Cell-sized condensed collagen microparticles for preparing microengineered composite spheroids of primary hepatocytes. Lab. Chip. 2015, 15, 3941-51.
62. Singh, S.; Chu, W. Y.; Ostadsharif Memar, R.; De Carlo, A.; Veres, T.; Günther, A. Scalable preparation of macroporous collagen microgels by air bubble-induced breakup and ice templating. React. Chem. Eng. 2024, 9, 2584-98.
63. Chen, M. W.; Fan, D.; Liu, X.; et al. Water Transport-induced liquid-liquid phase separation facilitates gelation for controllable and facile fabrication of physically crosslinked microgels. Adv. Mater. 2024, 36, 2405109.
64. Keshaw, H.; Thapar, N.; Burns, A. J.; et al. Microporous collagen spheres produced via thermally induced phase separation for tissue regeneration. Acta. Biomater. 2010, 6, 1158-66.
65. Miyata, T.; Namiki, S. Substrate consisting of regenerated collagen fibrils and method of manufacturing same. US4565580A, 1986.
66. Zeng, Q.; Zhang, M.; Adhikari, B. P.; Mujumdar, A. S. Effect of drying processes on the functional properties of collagen peptides produced from chicken skin. Drying. Technol. 2013, 31, 1653-60.
67. Nagarajan, U.; Kawakami, K.; Zhang, S.; Chandrasekaran, B.; Unni Nair, B. Fabrication of solid collagen nanoparticles using electrospray deposition. Chem. Pharm. Bull. 2014, 62, 422-8.
68. Yao, R.; Zhang, R.; Lin, F.; Luan, J. Injectable cell/hydrogel microspheres induce the formation of fat lobule-like microtissues and vascularized adipose tissue regeneration. Biofabrication 2012, 4, 045003.
69. Bielajew, B. J.; Hu, J. C.; Athanasiou, K. A. Collagen: quantification, biomechanics and role of minor subtypes in cartilage. Nat. Rev. Mater. 2020, 5, 730-47.
70. Parenteau-Bareil, R.; Gauvin, R.; Berthod, F. Collagen-based biomaterials for tissue engineering applications. Materials 2010, 3, 1863-87.
71. Adepu, S.; Ramakrishna, S. Controlled drug delivery systems: current status and future directions. Molecules 2021, 26, 5905.
72. Ren, X.; Zhao, M.; Lash, B.; Martino, M. M.; Julier, Z. Growth factor engineering strategies for regenerative medicine applications. Front. Bioeng. Biotechnol. 2020, 7, 469.
73. Mitchell, A. C.; Briquez, P. S.; Hubbell, J. A.; Cochran, J. R. Engineering growth factors for regenerative medicine applications. Acta. Biomater. 2016, 30, 1-12.
74. Sivaraj, D.; Chen, K.; Chattopadhyay, A.; et al. Hydrogel scaffolds to deliver cell therapies for wound healing. Front. Bioeng. Biotechnol. 2021, 9, 660145.
75. Sulaiman, S. B.; Idrus, R. B. H.; Hwei, N. M. Gelatin microsphere for cartilage tissue engineering: current and future strategies. Polymers 2020, 12, 2404.
76. Sharma, K.; Porat, Z.; Gedanken, A. Designing natural polymer-based capsules and spheres for biomedical applications - a review. Polymers 2021, 13, 4307.
77. Chan, B. P.; Hui, T. Y.; Wong, M. Y.; Yip, K. H. K.; Chan, G. C. F. Mesenchymal stem cell-encapsulated collagen microspheres for bone tissue engineering. Tissue. Eng. Part. C. Methods. 2010, 16, 225-35.
78. Nii, T. Strategies using gelatin microparticles for regenerative therapy and drug screening applications. Molecules 2021, 26, 6795.
79. Shi, M.; Gao, Y.; Lee, L.; et al. Adaptive gelatin microspheres enhanced stem cell delivery and integration with diabetic wounds to activate skin tissue regeneration. Front. Bioeng. Biotechnol. 2022, 10, 813805.
80. Smit, N. W.; Ten Sande, J. N.; Parvizi, M.; et al. Recombinant human collagen-based microspheres mitigate cardiac conduction slowing induced by adipose tissue-derived stromal cells. PLoS. ONE. 2017, 12, e0183481.
81. Yao, L.; Phan, F.; Li, Y. Collagen microsphere serving as a cell carrier supports oligodendrocyte progenitor cell growth and differentiation for neurite myelination in vitro. Stem. Cell. Res. Ther. 2013, 4, 109.
82. Liu, K.; Meng, C.; Lv, Z.; et al. Enhancement of BMP-2 and VEGF carried by mineralized collagen for mandibular bone regeneration. Regener. Biomater. 2020, 7, 435-40.
83. Mumcuoglu, D.; Fahmy-Garcia, S.; Ridwan, Y.; et al. ; FUJIFILM Manufacturing Europe B. V., Oudenstaart 1, 5047 TK Tilburg, the Netherlands. Injectable BMP-2 delivery system based on collagen-derived microspheres and alginate induced bone formation in a time- and dose-dependent manner. Eur. Cell. Mater. 2018, 35, 242-54.
84. Siverino, C.; Fahmy-garcia, S.; Mumcuoglu, D.; et al. Site-directed immobilization of an engineered bone morphogenetic protein 2 (BMP2) variant to collagen-based microspheres induces bone formation in vivo. Int. J. Mol. Sci. 2022, 23, 3928.
85. Hachim, D.; Whittaker, T. E.; Kim, H.; Stevens, M. M. Glycosaminoglycan-based biomaterials for growth factor and cytokine delivery: making the right choices. J. Controlled. Release. 2019, 313, 131-47.
86. Mumcuoglu, D.; De Miguel, L.; Jekhmane, S.; et al. Collagen I derived recombinant protein microspheres as novel delivery vehicles for bone morphogenetic protein-2. Mat. Sci. Eng. C. 2018, 84, 271-80.
87. Li, Q.; Chang, B.; Dong, H.; Liu, X. Functional microspheres for tissue regeneration. Bioact. Mater. 2023, 25, 485-99.
88. Jeevithan, E.; Qingbo, Z.; Bao, B.; Wu, W. Biomedical and pharmaceutical application of fish collagen and gelatin: a review. J. Nutr. Ther. 2013, 2, 218-27.
89. Zhao, X.; Xi, Y.; Zhang, Y.; et al. Redox-sensitive gelatin/silica-aptamer nanogels for targeted siRNA delivery. Nanoscale. Res. Lett. 2019, 14, 273.
90. Liu, Y.; Chen, L.; Shi, Q.; Zhao, Q.; Ma, H. Tumor microenvironment-responsive polypeptide nanogels for controlled antitumor drug delivery. Front. Pharmacol. 2021, 12, 748102.
91. Pires Figueiredo, M.; Rodríguez-Fernández, S.; Copes, F.; Mantovani, D. Review of collagen type I-based hydrogels: focus on composition-structure-properties relationships. npj. Biomed. Innov. 2025, 2, 16.
92. Guzdek, B.; Fołta, K.; Staniek, N.; Stolarczyk, M.; Krukiewicz, K. Collagen-based drug delivery agents for glioblastoma multiforme treatment. Int. J. Mol. Sci. 2025, 26, 6513.
93. Rosenblum, D.; Joshi, N.; Tao, W.; Karp, J. M.; Peer, D. Progress and challenges towards targeted delivery of cancer therapeutics. Nat. Commun. 2018, 9, 1410.
94. Gao, F.; Yin, J.; Chen, Y.; Guo, C.; Hu, H.; Su, J. Recent advances in aptamer-based targeted drug delivery systems for cancer therapy. Front. Bioeng. Biotechnol. 2022, 10, 972933.
95. Mitchell, M. J.; Billingsley, M. M.; Haley, R. M.; Wechsler, M. E.; Peppas, N. A.; Langer, R. Engineering precision nanoparticles for drug delivery. Nat. Rev. Drug. Discovery. 2021, 20, 101-24.
96. Riley, L.; Schirmer, L.; Segura, T. Granular hydrogels: emergent properties of jammed hydrogel microparticles and their applications in tissue repair and regeneration. Curr. Opin. Biotechnol. 2019, 60, 1-8.
97. Truong, N. F.; Kurt, E.; Tahmizyan, N.; et al. Microporous annealed particle hydrogel stiffness, void space size, and adhesion properties impact cell proliferation, cell spreading, and gene transfer. Acta. Biomater. 2019, 94, 160-72.
98. Widener, A. E.; Roberts, A.; Phelps, E. A. Granular hydrogels for harnessing the immune response. Adv. Healthc. Mater. 2024, 13, 2303005.
99. Yin, Y.; He, X.; Wang, J.; et al. Pore size-mediated macrophage M1-to-M2 transition influences new vessel formation within the compartment of a scaffold. Applied. Materials. Today. 2020, 18, 100466.
100. Chung, H.; Choi, J.; Hong, C.; et al. A micro-fragmented collagen gel as a cell-assembling platform for critical limb ischemia repair. Bioact. Mater. 2024, 34, 80-97.
101. Li, Y.; Bai, X.; Ren, C.; Ma, Y.; Liu, Y. Construction of injectable collagen-microgel/tannic acid/nano-hydroxyapatite granular hydrogel and evaluation of its potential in wound healing. J. Bioact. Compat. Polym. 2023, 38, 325-39.
102. Tuftee, C.; Alsberg, E.; Ozbolat, I. T.; Rizwan, M. Emerging granular hydrogel bioinks to improve biological function in bioprinted constructs. Trends. Biotechnol. 2024, 42, 339-52.
103. Yu, S.; Luo, Y.; Chen, S.; Fan, J.; Zhang, H. Quantitative assessment of hydrogel printability in extrusion bioprinting. Gels 2026, 12, 189.
104. Ma, S.; Mukherjee, N.; Mikhailova, E.; Bayley, H. Gel microrods for 3D tissue printing. Adv. Biosys. 2017, 1, 1700075.
105. Ataie, Z.; Kheirabadi, S.; Zhang, J. W.; et al. Nanoengineered granular hydrogel bioinks with preserved interconnected microporosity for extrusion bioprinting. Small 2022, 18, 2202390.
106. Feng, Q.; Li, D.; Li, Q.; et al. Assembling microgels via dynamic cross-linking reaction improves printability, microporosity, tissue-adhesion, and self-healing of microgel bioink for extrusion bioprinting. ACS. Appl. Mater. Interfaces. 2022, 14, 15653-66.
107. Kozlowski, M. T.; Crook, C. J.; Ku, H. T. Towards organoid culture without Matrigel. Commun. Biol. 2021, 4, 1387.
108. Jee, J. H.; Lee, D. H.; Ko, J.; et al. Development of collagen-based 3D matrix for gastrointestinal tract-derived organoid culture. Stem. Cells. Int. 2019, 2019, 1-15.
109. Li, C.; An, N.; Song, Q.; et al. Enhancing organoid culture: harnessing the potential of decellularized extracellular matrix hydrogels for mimicking microenvironments. J. Biomed. Sci. 2024, 31, 96.
110. Sachs, N.; Tsukamoto, Y.; Kujala, P.; Peters, P. J.; Clevers, H. Intestinal epithelial organoids fuse to form self-organizing tubes in floating collagen gels. Development 2017, 144, 1107-12.
111. Deng, S.; Zhao, X.; Zhu, Y.; et al. Efficient hepatic differentiation of hydrogel microsphere-encapsulated human pluripotent stem cells for engineering prevascularized liver tissue. Biofabrication 2022, 15, 015016.
112. Ruider, I.; Pastucha, A.; Raich, M. K.; et al. Accelerated maturation of branched organoids confined in collagen droplets. Lab. Chip. 2025, 25, 5043-54.
113. Liu, J.; Du, C.; Chen, J.; et al. Hydrogel microspheres empowering organ-on-a-chip systems: innovations and applications. Small 2025, 21, 2504563.
115. Li, K.; He, Y.; Jin, X.; Jin, K.; Qian, J. Reproducible extracellular matrices for tumor organoid culture: challenges and opportunities. J. Transl. Med. 2025, 23, 497.
116. Gjorevski, N.; Sachs, N.; Manfrin, A.; et al. Designer matrices for intestinal stem cell and organoid culture. Nature 2016, 539, 560-4.
117. Cruz-Acuña, R.; Quirós, M.; Farkas, A. E.; et al. Synthetic hydrogels for human intestinal organoid generation and colonic wound repair. Nat. Cell. Biol. 2017, 19, 1326-35.
