fig1

Figure 1. Sources of mtDNA perturbations include DNA damage and errors associated with replication machinery resulting in mutations or deletions. Different mechanisms involved in mtDNA quality control: a: mtDNA damage repair, b: mtDNA degradation via POLG, c: degradation of mitochondria containing mutated or damaged mtDNA via mitophagy, or d: selective replication of wild-type mtDNA. Each of these mechanisms (with literature references) is discussed in detail in the main text.