fig7

Figure 7. Effects of the secretome on inflamed chondrocytes. (A) Gene expression modulation in chondrocytes either untreated or treated with IL, and subsequently untreated or treated with F, P, and S/X secretomes (pooled from 8 donors each). Values are reported as fold relative to untreated (CTRL) cells. The color code ranges from green (downregulation) to red (upregulation) relative to CTRL. (B) R-squared correlation values for the gene expression ratios for the different conditions in chondrocytes, either untreated or treated with IL and secretomes (F, P, S/X). The color scale ranges from red (low correlation) to green (high correlation). (C) Principal component analysis of gene expression modulation as shown in (A). The X- and Y-axes represent principal components 1 and 2 that explain 83.2% and 9.5% of the total variance, respectively. IL: Interleukin 1β-treated cells. F: fetal bovine serum; P: platelet lysate; S/X: serum/xeno free.