fig4

From: Towards extracellular vesicle delivery systems for tissue regeneration: material design at the molecular level

Figure 4. In vivo tracking of EVs released from hydrogels. (A) Fluorescence microscopy of PKH-26 red-labeled hUCMSC-EVs released by the MMP-responsive hydrogel in the border region of myocardial infarction; (B) Live and ex vivo imaging of PKH-26 red-labeled EV delivery PEG hydrogels crosslinked by thiol-maleimide conjugation in the chronic liver injury model; (C) Live imaging of Gaussia luciferase-labeled MSC-EVs encapsulated in chitosan-β-glycerophosphate hydrogel injected in ischemic hindlimb. Figure 4A adapted with permission^[122], Copyright 2019, Royal Society of Chemistry; 4B adapted with permission^[62], Copyright 2019, American Chemical Society; 4C adapted with permission^[126], Copyright 2018, American Chemical Society. EVs: Extracellular vesicles; PEG: poly(ethylene glycol); MSC: mesenchymal stem cell.