fig2

Figure 2. Anatomical structure and location of EVs in the male reproductive system. The primary components of the male reproductive tract (A) consist of the testes where sperm are made, the epididymis where sperm mature, the vas deferens which transports sperm to the seminal vesicles and prostate gland which produce seminal plasma, the urethra, and the penis. EVs have been identified in the testes (B) and may influence sperm production. EVs found in the epididymis (C) are referred to as epididymosomes. EVs in seminal fluid are produced by the seminal vesicles and prostate and are mixed with sperm as it enters the urethra (D). EVs: Extracellular vesicles.