fig5

Figure 5. Graphical abstract. All Yorkshire swine age 11 weeks had an ameroid constrictor placed to the left circumflex artery. Two weeks later oral therapy was started with vehicle (“CON”, n = 8), sitagliptin (“SIT”, n = 5), or canagliflozin (“CANA”, n = 8) daily. Five weeks after treatment cardiac functional analysis was performed and tissue was harvested for further analysis. Main findings included improved cardiac function with CANA compared to SIT, similar improvements in perfusion with the two treatment agents, and improved microvascular density with SIT. Possible mechanisms implicated in coronary perfusion and collateralization are also outlined. CON: Control; SIT: sitagliptin; CANA: canagliflozin; MCP-1: monocyte chemoattractant protein 1; TGFß: tumor growth factor beta; FGFR1: fibroblast growth factor receptor 1; ICAM 1: intercellular adhesion molecule 1.