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Figure 4. Summary of the contribution of Th17 cells in NAFLD and the related pathologies. The ellipse on the left shows the dynamics of Th17 cells in peripheral blood and adipose tissue in obesity and type 2 diabetes (T2DM) in humans, while the ellipse on the right shows the dynamics of Th17 cells in adipose tissue, mesenteric lymph nodes, and small intestinal mucosa in obese mice. The central square summarizes the Th17 cell dynamics in the peripheral blood and liver tissue in NAFLD. The left side shows the dynamics in humans, and the right side shows the dynamics in mice. NAFLD: Non-alcoholic fatty liver disease; NAFL: non-alcoholic fatty liver; NASH: non-alcoholic steatohepatitis; SAT: subcutaneous adipose tissue; VAT: visceral adipose tissue; Th: T helper; HFD: high-fat diet.