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Figure 3. Elevated expression of SRC-3 in human ATC. (A) Immunohistochemistry (IHC) images for SRC-3 (I), their magnified images (×2) showing nuclear staining of SRC-3 (II), and quantitative analysis for the IHC results (III) in different stages of human thyroid cancer. (B) IHC images for Ki-67 (I) in normal thyroid, PTC, and ATC, and correlation plot showing strong positive relationship between SRC-3 and Ki-67 expression in ATC (II). Significant differences were indicated by asterisks (****P < 0.0001). Scale bars represent 50 μm. ATC: Anaplastic thyroid cancer; FTC: follicular thyroid cancer; PTC: papillary thyroid cancer^[147]. (Permission from the authors).