fig5

Figure 5. The changes in the resonance Raman fingerprints represented by the ratios of peak intensities of biomarkers. The 1,589 cm^-1 mode is supposed to be arising from tryptophan; 1,452 cm^-1 mode is assigned to fatty acids-lipid protein molecules; 1,662 cm^-1 mode is amide I combined with type I collagen; the largest ratio (I1589 to I1452) changes occurred at a depth of 100 µm in the BCC tissue (left). Based on student’s t-test, the difference between normal and BCC samples is shown to be statistically significant (P < 0.05) for all biomarkers. BCC: basal cell carcinoma